Differences

This shows you the differences between two versions of the page.

--- health:dietary-supplements [2025/11/01 05:43] – [20250911] marcos
+++ health:dietary-supplements [2025/11/01 16:47] (current) – [20251101] marcos
@@ Line 155: / Line 155: @@
 Should SAMe, ALA, ALCAR, NAC, and/or Creatine be taken on an empty stomach or with food or doesn't matter?
+---
+Piperine (example: black pepper has 5-7% average by weight)
+<WRAP center round box 95%>
+The reason for the different findings in terms of paternal reproductive toxic effects of these four studies compared to a sub-chronic 90-day animal toxicity study [29] remains elusive. The major difference seems to lie in the method of piperine administration: in the sub-chronic 90-day animal study, piperine was administered via feed, resulting in multiple intakes of small piperine quantities spread throughout the day. In the case of the other four abovementioned animal studies, piperine administration as a bolus can be assumed, possibly resulting in higher peak blood or tissue levels or otherwise increased bioavailability.\\
+[[https://doi.org/10.3390/foods10092121 |Safety Aspects of the Use of Isolated Piperine Ingested as a Bolus, Ziegenhagen et al 2021]]
+</WRAP>

Hacks by Mekineer